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Reviva IVF

IVF treatments in India boasts lower cost, yet higher success rates

IVF treatments in India boasts lower cost, yet higher success rates

IVF treatments in India

IVF or In vitro fertilization treatments are popular all over the world. However, the attention of IVF treatment seekers has turned to India as their choice of the treatment location. Many people from the western world are visiting India for this purpose.

Cost of IVF Treatment in India

Affordability of the cost of IVF treatment in India coupled with excellent success rates attract many couples from all over the world, and their confidence to choose India as their IVF treatment destination has increased over time. The average cost of the IVF treatment in India is usually between Rs. 250,000 – 450,000 for a basic IVF treatment cycle. However, advanced IVF treatment as if ICSI (Intracytoplasmic sperm injection) or ET (Embryo transfer) costs 120,000 – 150,000 in addition to the IVF basic treatment cycle cost. This is only a fraction of a treatment cost when compared with the IVF treatment costs in the western world.

In addition, the cost of IVF treatment hugely varies between various cities of India. The cost of IVF treatment in Delhi is totally different from treatment cost in Mumbai or in Chennai. Due to this reason, many couples who live in different parts of India travel to other locations to undergo these IVF treatments at an affordable cost.

Here is how the infertility treatment cost in India varies according to the location

City Price
Mumbai 200,000 – 300,000
Bangalore 160,000
Chennai 145,000 – 160,000
Delhi 90,000 – 125,000
Nagpur 75,000 – 90,000
Pune 65,000 – 85,000
Hyderabad 70,000 – 90,000

The treatment cost in Chandigarh is considerably low when compared with some of the locations above, and at Reviva clinic you could receive world-class medical care for the same cost.

Additional Costs Associated With IVF Treatment

Every couple should keep in mind to analyze the package that comes with the IVF treatment beforehand in order to avoid any hidden charges. For instance, Reviva Infertility and IVF Clinic offer special IVF package that includes all examinations costs as if for ultrasound examination, the cost for all types of blood tests that required during IVF treatment, anesthesia cost, advanced IVF treatment cycle options as if ICSI and ET.

Besides, Reviva clinics package also incorporates laboratory charges and even it includes the cost of day care hospitalization that is required during IVF treatment cycle and guarantee of no hidden fees. All charges are included and elaborated in the treatment packages so that preparing for the treatments financially would not bring any surprises throughout the process.

Conclusion

As India is one of the countries to receive infertility treatments for a lower cost, you should consider visiting Reviva Clinic at Chandigarh to make your dream come true. Along with the lower cost of treatments, the lower costs of accommodation and also travelling will reduce additional costs you will have to bear during the visits. That is why many people consider India today as to be a leading country for medical tourism. If you are planning for IVF treatments and wondering where to seek the best care, then you are in the right place. Reviva clinic is more than happy to hear from you

Oocyte Grading

Oocyte Grading

Oocyte Grading

Understanding Oocyte Development and Grading

    An oocyte is a female gamete which is involved in reproduction. It is one of the largest cells in the body 120 microns in diameter and develops in the ovarian follicle during oogenesis. On the basis of oocyte grading we can find the ideal oocyte for fertilization. While Oocyte Pickup, on the basis of cumulus we can get an idea of oocyte maturity.

    • Immature – The immature oocytes are Germinal Vesicle and they have tightly packed corona cells with little cumulus.
    • Intermediate– The nuclear maturity of these oocytes is Metaphase I. The corona and cumulus cells are tightly packed.
    • Mature- These oocyte are at Metaphase II stage and they appear like sunburst of corona cells with expanded and abundant cumulus.
    • Postmature– These types of oocytes are mature ones which have dark Cumulus oocyte complex. In which corona cells begin to degenerate.

    On denudation of cumulus–corona cells, we can better appreciate the maturity and morphology of oocyte before fertilization. Below given picture can give you an idea about the oocytes maturity.

    • Germinal vesicle: has a visible intracytoplasmic nucleus. Metaphase I oocyte neither has Germinal Vesicle nor polar body. Metaphase II stage when it has a visible polar body.

    We can grade the oocytes by looking at its Zona Pellucida, perivitelline space (PVS ) shape, polar body (PB) morphology , Ooplasm characteristics.

    • Zona Pellucida:  The Zona Pellucida is the outer layer of oocyte .The normal thickness of ZP is 17-18 microns. If the thickness of Zona is greater than normal then after ICSI Laser Assisted hatching (LAH) is required. If thickness is very low then there is a chance of early hatching or damage can cause to oocyte while doing denudation. The alterations in Zona Pellucida appearance could be caused by secretion problems of the glycoprotein matrix.

    Zona Pellucida AssessmentExplanation
    NormalThickness of 17-18 microns with even surface
    ThinIf the Zona pellucida is less than normal
    ThickIf Zona pellucida is more than 25 microns
    AbnormalIf the shape of Zona pellucida is irregular
    • Perivitelline Space: This is the space between Zona and oolemma membrane known as PV space. We can see a polar body in this space. Sometimes it is large in size or may be absent.

    Perivitelline Space AssessmentExplantion
    Normal
    The Ooplasm is slightly away from the ZP in the surrounding area of the polar body
    Large
    the Ooplasm is away from the ZP leaving a large space around the cytoplasm
    FragmentedFragments and debris
    • Polar Body: The polar body should single and round in shape and in total 5% of the cell volume.

    Polar body AssessmentExplanation
    Normal
    Ovoid & round in shape, with 5% of cell volume.
    Fragmented
    Polar body is irregular and dissociating into small fragments
    GiantLarge in size
    • Ooplasm: The Ooplasm is the cytoplasm of egg. Sometimes it has some inclusions and clusters which can be graded to get the best oocyte.

    Cytoplasmic InclusionsExplanation
    Vacuoles
    These are fluid filled bodies. Appears as a vesicle in the cytoplasm. They can be single or abundant.
    Refractile Bodies
    Appears like dark dots of diverse sizes (lipofucsin)
    Smooth Endoplasmic reticulumAppears as a flat elliptical disk
    GranulationUneven patches of granules in the Ooplasm

    From such assessment we can only find the ideal oocyte for fertilization. But these parameters are still controversial for embryo development and implantation. Like abnormal Zona Pellucida, Perivitelline space fragments, size and morphology are still controversial. But the presence of inclusions bodies like vacuoles, Refractile bodies , SER in large number can be detrimental.

    Reviva Clinic – One of The Best in IVF Treatments

    Reviva Clinic – One of The Best in IVF Treatments

    The Best IVF Treatments in Chandigarh

    Infertility has become a more frequent problem today. The modern lifestyle and environmental factors have been able to affect the fertility of many men and women in a significant way. If you are one of those living in the anguish and thinking about an IVF treatment, India could be the best place to visit for your treatments.

    India is one of the leading destinations for advanced IVF treatments in the world today. Therefore, it is no surprise that many infertile patients from around the world come to India gathering their hope to succeed. While there are many IVF centers in different parts of the country, the best IVF center in India, namely Reviva clinic is located in Chandigarh. As Reviva clinic boasts about its highest success rate, the number of patients visiting for treatments has significantly increased each year and is still on the rise.

    India is one of the most medically advanced countries in Asia and possesses all know-how strategies and modern technology to treat men and women who look forward to having a child. Reviva clinic being the best IVF center in Chandigarh possesses the modern technology and access to advanced interventions, which were once available only in the leading countries of the Western world. Today, you can visit Reviva clinic and experience the state-of-the-art medical care and be sure of a higher success rate. While you get treated at the best IVF center in India for your treatments, you can also enjoy the calming nature, warm hospitality and a rich culture that will even increase your hopefulness towards success.

    Nothing is more comforting than being surrounded by a team of medical specialists who understands and work towards your success. This is what the Reviva Clinic – the best IVF center in Chandigarh has expertise in. A group of specialized medical professionals works together in the IVF centre, and they prioritize the individual needs of every patient in order to achieve success.

    One of the best reasons to get IVF treatments in India is the lower cost. Yes, although Reviva clinic is the best IVF center in India, the cost is almost as half as of that is in the advanced countries of the world. State of the art, advanced strategies, and modern interventions would not be accessible at a lower cost in any other part of the world as you would in India. This has allowed many couples to save money for their childbirth rather than spending it all on the IVF treatments.

    Reviva clinic is not only specialized in IVF treatments but also carry out other advanced fertility treatments such as ovulation induction, follicular monitoring, IUI, surgical sperm retrieval, oocyte donation, etc. You could find many solutions under a single roof, and that is why we say that Reviva clinic is the best IVF center in Chandigarh.

    If you are looking forward to making your dream come true and to get the world’s best medical care, then you are in the right place. Come and get treated in the best IVF center in India!

    Ovarian Rejuvenation

    Ovarian Rejuvenation

    Ovarian Rejuvenation
    Revolution in the medical sciences provides a chance to women to revitalize their ovaries by a therapy called ovarian rejuvenation. The therapy offers hope to those patients who have problems like low Oocyte reserve, premature ovarian failure, early menopause problems, and Anti-Mullerian hormone levels.

    It is a fact that, a woman is born with millions of Oocyte in her ovaries and as she grows up the egg supply declines in number and in quality as well. It seems quite impossible to develop new eggs in the ovaries naturally. But, according to the recent researches, it is possible to regenerate new eggs with the help of patient’s blood cells. Blood cells have growth factors which help to heal various types of injuries in the body. Growth factors can stimulate the growth of new blood vessels, nerve and connective tissues by the activation of Stem Cells.  And stem cells have a power of regeneration.

    Ovarian Rejuvenation Procedure

    Ovarian rejuvenation can be done on anytime on women with or without menstruation cycle. The procedure has two steps:

    Step 1:

    The First step is to isolate the PRP (Platelet-rich plasma), Preparation of PRP begins with the insertion of a needle into the vein in order to get blood in the test tubes. Platelets and White blood cells (WBCs) are separated from the red blood cells (RBCs) and serum by centrifugation process which takes approximately one hour to prepare PRP.

    Step 2:

    The Second step is Administration of PRP into Ovaries, under an intravenously administered anaesthesia. The isolated PRP (supplied with protein-rich growth factor and stem cell chemoattractants) is injected into the ovaries specifically in the cortical tissue of the patient with the help of transvaginal ultrasound.

    Ovarian Rejuvenation has the utmost benefit that it gives a chance to women to become pregnant from her own eggs naturally and also helps in improvement in hormone levels.

    After Procedure Precautions

    After the procedure, it is very important to keep an eye on AMH (anti-Mullerian hormone), FSH, LH and Estradiol levels along with the ovarian function for 1- 3 months. The values will help to know the positive working of ovarian rejuvenation. Usually, the improvement shows up in 1-3 months but in some cases, it takes more than that. So, the monitoring is done up to 6 months. But the treatment is still in research phase. If ovarian rejuvenation treatment shows a promising future, and then it could help many women who have various types of age-related infertility problems.

    Has the time come for single embryo transfer?

    Has the time come for single embryo transfer?

    single embryo transfer

    Innovative techniques are persistently growing for infertility treatment. The evolving industry is giving great expectations to most of the people who want to experience parenthood. It seems exciting to be a mother of more than 1 baby and is often a happy moment for every parent. But in multiple pregnancies, there is a risk of complications like premature birth, congenital abnormalities, and mother will more likely to have health issues like gestational diabetes, anaemia, and high blood pressure.  In addition to this, a premature baby needs special care in the Intensive care unit (ICU). So, single embryo transfer (SET) is good option to overcome these problems. Single-embryo transfer (SET) is a process in which one high-quality embryo is placed into the uterus. So, the main focus is to reduce the twin rates in pregnancy by using the single embryo transfer technique.

    In the recent years, SET has extensively accepted due to the reason that it reduces the possibility of twins and triplets and also it is safe for both baby and mother. According to the American Society of Reproduction Medicine, single embryo transfer should be considered for patients with favourable prospects usually women who are under the age of 35 or younger with good quality eggs.

    Single Embryo transfer (SET) is done when the embryo is at the blastocyst stage. And it is the stage when the best quality embryos can be identified more accurately. A blastocyst stage transfer is a more viable embryo for transfer which reduces the multiple pregnancies. Nowadays, the embryo screening technologies are highly developed, through which embryologist are able to get best single embryo with the goal of achieving a good singleton pregnancy and which reduces the possibilities of multiple gestation and miscarriages.

    Through, cryopreservation technology embryos are preserved in frozen condition with no risk even after they have been cultured in the lab to the blastocyst stage. With the help of advanced tools, embryologists can provide the appropriate environment for embryos to grow, as well as methods to recognize that embryo which is likely to develop a baby. This contributes to the probability of success on the first embryo transfer as well as successive transfers.

    Due to the advancement of the technology, the majority of patients are able to conceive through single embryo transfer. Success rates of Single embryo transfer (SET) have increased considerably over the past 5 years, making it nearly as likely to achieve a successful pregnancy embryo as with two or more embryos.

    Why a trend from fresh to frozen embryo transfer?

    Why a trend from fresh to frozen embryo transfer?

    frozen embryo transfer

    Whenever a sudden shift is made from fresh embryo transfer to frozen embryo transfer the couple usually have many queries in mind. So, let’s evaluate both and see pros and cons.

    Fresh embryos transfer is undergoing ovarian hyper stimulation making of embryos and transferring resultant embryos to uterine cavity in same cycle. In frozen embryo transfer first two steps of controlled ovarian hyper stimulation and process of IVF/ICSI are same but the resultant embryos are frozen using vitrification techniques and not transferred in same cycle. They are thawed and then kept uterine cavity after preparing the uterine cavity.

    In patients who are normal or hyper responders the frozen embryo transfers are known to have better results than the fresh embryo transfer . The reason can be that due to ovarian hyper stimulation and high levels of estrogen may have negative impacts on the endometrial receptivity. In some cycles another hormone called progesterone may also be raised, which again decreases embryo implantation rate. Whereas in frozen embryo transfer the body and uterus have already recovered from the impact of hormonal disturbance and hence more receptive.

    Because of their reason in patient with PCOS the frozen embryo transfer is associated with higher live birth rate. It also reduces complications like ovarian hypertimulation in these patients.

    Another reason where we make a sudden shift from fresh to frozen embryo transfer are when the ovarian stimulation part is good but the endometrial thickness fails to reach an optimal level.

    So because of the above reasons we are moving towards more frozen transfer than fresh transfers in self cycle.

    Preparing for Donor Eggs IVF Cycle – Psychological Issues

    Preparing for Donor Eggs IVF Cycle – Psychological Issues

    Preparing for Donor Eggs

    In about 50% of our patients, being taken for IVF, the oocyte quality or quantity is the major concern. It’s very easy for us to show you the path of egg donation as it is a routine for us. But we know it is not that simple for you. Though it carries a very high success rate, but psychological implications on the recipient are very high.

    The major indications for IVF with donor oocytes in Reviva are –

    • Premature ovarian failure
    • Menopause
    • Decreased ovarian reserve
    • Endometriosis
    • Recurrent self cycle failures with no proven endometrial or male factor.
    • Genetic causes.

    It takes time for the couple to accept the option of Donor eggs, but usually the desire of having a family overcomes this hesitation.

    The most important concern of the couple is the quality of genes transmitted to the child. Though the anonymous egg donor is being matched to the recipient as far as possible, the concern always remains in majority of recipient; they are satisfied with their gestational contribution which creates a strong bond.

    Another way of dealing with it is to keep the information of type of cycle between the couple only, it will serve you from interrogation eyes and any future problems will be avoided.

    On positive note egg donation is associated with many benefit. The most important since eggs are derived from a young woman, they are more likely to produce chromosomally normal embryos and so risk of abortions and birth defects is less.

    So, though egg donation is not the first choice of anyone, but it is treatment with very high success rate where it is indicated.

    Can Adenomyosis affect my fertility

    Can Adenomyosis affect my fertility

    Can Adenomyosis affect fertility

    What is Adenomyosis?

    Adenomyosis is a condition in which the cells of endometrium (the uterine lining) are present inside the muscular wall of uterus. There is also associated hypertrophy uterine muscles.

    How Adenomyosis Impacts Fertility?

    Adenomyosis can affect fertility in two ways. Firstly it effects the uterine contractions which helps sperms to reach the tubes. Secondly it also increases the number of toxic cells in the uterine lining which may effect the implantation of embryos.

    Adenomyosis and Endometriosis: How They Impact Fertility

    Adenomyosis may also be associated with endometriosis, a condition in which the uterine lining cells are present in the ovaries or other sites in pelvic. This may further effect the oocyte quality and number, further contributing to difficulty in conception.

    If you want to learn more about this conditions or have any concerns, you can ask our fertility experts.

    Fertility Preservation for Women Diagnosed with Cancer

    Fertility Preservation for Women Diagnosed with Cancer

    Fertility Preservation for Women
    The most common question asked in IVF counsellings is “Doctor, as we have heard, we need to do complete bed rest after embryo transfer or I can move around. Do you think 15 days leave is sufficient.” So it’s time to give away this myth forever now.

    Factors Affecting Implantation of Embryos

    The implantation of embryos placed inside your uterus after embryo transfer depends upon three most important factors:
    • Quality of eggs
    • Quality of sperms
    • Receptivity of endometrium.

    Debunking Myths for IVF Success

    Moreover uterus is a collapsed cavity with opposins walls and a closed cervix. If the embryos are placed inside the uterus at their proper position then few minutes after embryo transfer they remain at their same stable position and in no ways they will fall down even if you stand after the embryo transfer.

    Going by literature, various studies have been conducted in which pregnancy rates were compared between the groups who were made to get up 20 minutes after the embryo transfer and those made to rest for varying periods from 3 minutes to even 24 hours in some centers. But no difference was found in the pregnancy rate and the live birth rate. In certain systemic reviews and meta analysis it has been shown that complete bed rest might negatively affect the outcome of IVF/ICSI cycle and the cause may be stress and anxiety mechanism.

    So a lot of evidence is against the bed rest factor. Even at Reviva we have seen pregnancy rate comparable between the bed rest and no bed rest groups. I can recall many positive results even in those patients who jump out of bed even half an hour after transfer and those joining their offices the very next day. But inspite of clinical evidence we daily come across patients who had undergone failed cycles at other centers or one of their relatives had undergone treatment elsewhere and were advised complete bed rest after transfer and to the extent that they were kept hospitalized for 24 hours.

    All this increases the anxiety factor in the patient. Very obvious that lying on bed the whole day is not easy and the thought process is totally focused on one thing and more of stress and negative feelings. How do you think it’s going to help the success rate. And if unluckily the results negative than the female takes the whole burden on her. She thinks it didn’t work because she didn’t have sufficient rest.

    Piece of Advice

    So our advice to all our patients, don’t go on house arrest of 2 weeks. Take it easy and carry out with your normal activities. Rest is not going to influence your outcome. So relax, be normal and wait for nature to do its best.

    ENDOMETRIOSIS WHAT’S THE URGENCY ?

    ENDOMETRIOSIS WHAT’S THE URGENCY ?

    Endometriosis and Fertility

    What is Endometriosis?

    This is a clinical entity where the uterine lining cells are present outside the uterus, usually, ovaries. The incidence is in reproductive age group.

    This condition effects your chances of conceiving by decreasing number and quality of eggs, causing pelvic adhesions and hence tubal blockage toxic microenvironment and also effects endometrium receptivity. (2-10 % in women in general population and 20-30% in infertile group)

    Endometriosis and Fertility: Understanding the Impact

    Women with endometriosis are 5% less likely to continue naturally even in cases of mild endometriosis. In severe endometriosis the fertility decrease is much higher.

    Now since endometriosis is an on-going process, so when diagnosed we tell the patient to plan early. Even after surgical removal of endometriotic cyst, the non visible endometriotic spots continue to release toxins which can effect your fertility. And if patient doesn’t take any treatment after surgery and doesn’t conceive within six months, the pre-surgical state may come again. So postsurgery aggressive treatment is required in cases of grade 3-4 and those with grade 1 and 2 are advised to plan early either naturally or IUI.