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Fresh VS Frozen Embryo Transfers: An Explanation through Comparisons

Fresh VS Frozen Embryo Transfers: An Explanation through Comparisons

Fresh embryo transfers were the only option when In Vitro Fertilization (IVF) was initially introduced due to the limited progress in cryopreservation techniques.

However, over the past years, significant advancements in:

Nowadays Generally FET’s are preferred depending upon various factors: -

  • Age of couple
  • No of oocytes received
  • Quality of embryos
  • Hormonal parameters
  • Adequacy of endometrial lining

Fresh & Frozen Embryo Transfers

Understanding the Differences

Fresh Embryo Transfer

Frozen Embryo Transfer

The Benefits & Drawbacks of Fresh & Frozen Embryo Transfer

Advantages of Fresh Embryo Transfer:

  • The waiting time for fresh embryo transfer is shorter as embryos are transferred soon after fertilization.
  • The embryos are not subjected to the stress of freezing & thawing.
  • Fresh cycle involves the process of ovarian stimulation, which can result in a receptive endometrial lining, if the women is not hyper – responded.

Disadvantages of Fresh Embryo Transfer

  • Ovarian stimulation during fresh cycles may result in OHSS (ovarian hyperstimulation syndrome), a potentially serious condition marked by enlarged & painful ovaries.
  • Fresh transfer is time critical & need to be synchronized with the natural menstrual cycle, providing limited flexibility in terms of timing.

Advantages of Frozen embryo Transfer

  • FET provides a couple who have encountered challenging situations like cancer treatments with the opportunity to have children once their treatments are successfully completed.
  • Reduced risk of ovarian hyperstimulation.

Disadvantages of frozen embryo transfer

  • Not every embryo can withstand the freezing & thawing process, which could lead to a reduced no. of embryos available for transfer.
  • Going through frozen embryo transfer can be quite time consuming.

Factors to consider when deciding between fresh or frozen embryo transfer

  • Personal health
  • Timing flexibility
  • Success rate

NOTE: REVIVA IVF & Fertility Clinic in Chandigarh provides advanced fertility preservation methods. Our dedicated healthcare team serves exceptional care with precision & expertise in reproductive healthcare. For specialized assistance with embryo transfer, reach out REVIVA IVF & fertility Clinic

For more information contact us at :8288028667

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How To Select Your IVF Clinic in Chandigarh

How To Select Your IVF Clinic in Chandigarh

IVF is an extensive procedure that may involve frequent visits to the clinic, regular talks with your doctor, and the need for constant support. This is why it is important to choose an IVF centre in Chandigarh that gives you the required attention and treats you well.

But how do you find a good IVF clinic? What are the factors that you must consider? Our article today is all about it.

We will help you distinguish clinics based on multiple parameters including emotional support, care, and compassion, which are paramount in sensitive procedures like IVF.

Reach out to friends and family for referrals

We are strong advocates of referrals because personal experience is the most reliable form of feedback. If anyone you know has sought IVF treatment, reach out to them and ask them about the doctor/clinic. You can also ask the clinics you are interested in for referrals. Reputed clinics are usually happy to share the details.

While speaking to them, ask about the entire journey and their overall experience. This will help you learn if a clinic needs to be avoided completely.

Speak to the doctor directly

A hearty conversation with the doctor will tell you a lot about what you can expect. It is crucial to create a healthy relationship with the doctor who will treat you because he/she will be your support system for a long while.

Be open about your concern and see how the doctor responds. If he/she only seems interested in speaking about the treatment, it is a red flag. Genuine, compassionate doctors are willing to help you, answer your questions, and walk the path with you. These are the doctors you should seek.

Another very important factor here is the doctor’s time. Since IVF is not a one-session procedure, you have to be sure that the doctor has time for you, regardless of how many other patients he treats. This will be clear once you get in touch a couple of times and see how long you have to wait. After the first visit, even if you like the doctor thus, do not take hasty decisions or make the advance payment.

Will the treatment be customized?

In case the first cycle does not work, the doctor should ideally tweak the treatment for the next. Reputed doctors follow this approach because everyone’s condition is unique and the same template treatment may not work for everyone.

If your case is unique, do they have the required expertise?

Almost all clinics are well-equipped to deal with regular IVF procedures. But, if you have a difficult condition, this particular factor will be important for you. Even if the clinic/doctor has been in business for years, the experience will not count if they haven’t dealt with cases similar to yours. So, make sure you get that information from them as well.

How good is the clinic?

Since, along with the doctor, you will also be dealing with staff members, you should assess how good the clinic is. Here are a few things to ask yourself:

  • Is the staff courteous and kind?
  • Are all hygiene practices being followed?
  • Is the clinic a super-specialty clinic or multi-specialty clinic? Especially in these uncertain times, it is best to choose a super-specialty clinic. The doctors and staff members will be dedicated to IVF and not be distracted by other emergencies.
  • Do they have the latest equipment to cater to your condition? A little background research and a talk with your OB/GYN will help you understand this.

Are they being honest?

Pushy clinics are bad news. They will be too eager to push their services instead of honestly assessing your condition and helping you accordingly.

In case you need donor eggs, they may also push you to choose what they offer instead of letting you use your own eggs.

Such situations can be tricky but you can understand whether a clinic is trustworthy by the way they approach you, speak to you, and suggest a way forward. Good clinics will not be pushy or complacent. The doctor will not just advise but also give you reasons behind the recommendation.

IVF is an emotionally tiring process. Having an understanding doctor who supports you through the difficult journey will make it considerably easy. So, choose wisely.

Reviva IVF – Your friendly IVF clinic in Chandigarh

At Reviva IVF, we value our transparency over everything else. We strive to provide a customized treatment that is best suited to you and your health conditions. Our team of dedicated doctors will work closely with you right from day one to help your dream of being a parent come true. Get in touch with us and choose the best IVF centre in Chandigarh!

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Egg freezing Process

Egg freezing Process

Egg freezing is the process of freezing mature or immature oocytes below sub-zero temperatures. These oocytes can be thawed & matured under in vitro conditions & can be fertilized using appropriate technique. Good pregnancy rate have been seen from such embryos derived from oocyte freezing. In view of the fact that the egg freezing has drawn a lot of attention in the field of reproductive medicine, the indications for oocyte freezing are given below.

  • Women of reproductive age undergoing chemotherapy for cancer treatment.
  • Unable to get sperm for IVF/ICSI during treatment
  • Egg donation programme
  • When women wish to have family in the later stage due to their personal reasons.
  • History of premature ovarian failure (POF)
  • In PCOS patients when stimulation is merged with in vitro maturation (IVM) method.

Process of freezing

After egg retrieval, the embryologist (an expert in oocyte freezing) will wash & incubate the oocytes for approx 2 hrs. The process starts with the denudation in which the cumulus cells which surrounds the oocytes are denuded to know the maturity of eggs. During the freezing process, oocyte has to undergo various biological changes. Firstly, it is treated with Equilibration Solution (ES) – high concentration of penetrating cryoprotectants like glycerol DMSO, propanediol, etc which replace the water content of cell with cryoprotectants. Then the oocytes are treated with Vitrification solution (VS) which is a combination of permeating & non-permeating agents (Rafflose, Trehalose, etc). Then it is directly exposed to liquid nitrogen. Due to this highly viscous medium its forms a glassy substance at low temperature. The procedure is very rapid any delay can cause damage to the oocytes like spindle damage etc.

Advantages of Oocyte freezing:

  • Social egg freezing offered to women under the age of 38 yrs who want to start their family at later stages. It adds a possibility to have a healthy & genetically related child.
  • Fertility preservation for young women with cancer.
  • Reduces need of a donor
  • Reduces the number of treatment performed at advanced maternal ages.

A couple needs to understand the impact of age on their fertility. Egg freezing is an alternate option for those people who are facing such kind of problems as discussed in the above article.

For more information, you can reach us for more information.

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Ovarian Rejuvenation

Ovarian Rejuvenation

Revolution in the medical sciences provides a chance to women to revitalize their ovaries by a therapy called ovarian rejuvenation. The therapy offers hope to those patients who have problems like low Oocyte reserve, premature ovarian failure, early menopause problems, and Anti-Mullerian hormone levels.

It is a fact that, a woman is born with millions of Oocyte in her ovaries and as she grows up the egg supply declines in number and in quality as well. It seems quite impossible to develop new eggs in the ovaries naturally. But, according to the recent researches, it is possible to regenerate new eggs with the help of patient’s blood cells. Blood cells have growth factors which help to heal various types of injuries in the body. Growth factors can stimulate the growth of new blood vessels, nerve and connective tissues by the activation of Stem Cells.  And stem cells have a power of regeneration.

Ovarian rejuvenation can be done on anytime on women with or without menstruation cycle. The procedure has two steps:

The First step is to isolate the PRP (Platelet-rich plasma), Preparation of PRP begins with the insertion of a needle into the vein in order to get blood in the test tubes. Platelets and White blood cells (WBCs) are separated from the red blood cells (RBCs) and serum by centrifugation process which takes approximately one hour to prepare PRP.

The Second step is Administration of PRP into Ovaries, under an intravenously administered anaesthesia. The isolated PRP (supplied with protein-rich growth factor and stem cell chemoattractants) is injected into the ovaries specifically in the cortical tissue of the patient with the help of transvaginal ultrasound.

Ovarian Rejuvenation has the utmost benefit that it gives a chance to women to become pregnant from her own eggs naturally and also helps in improvement in hormone levels.

After the procedure, it is very important to keep an eye on AMH (anti-Mullerian hormone), FSH, LH and Estradiol levels along with the ovarian function for 1- 3 months. The values will help to know the positive working of ovarian rejuvenation. Usually, the improvement shows up in 1-3 months but in some cases, it takes more than that. So, the monitoring is done up to 6 months. But the treatment is still in research phase. If ovarian rejuvenation treatment shows a promising future, and then it could help many women who have various types of age-related infertility problems.

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Preparing for Donor Eggs IVF Cycle – Psychological Issues

Preparing for Donor Eggs IVF Cycle – Psychological Issues

In about 50% of our patients, being taken for IVF, the oocyte quality or quantity is the major concern. It’s very easy for us to show you the path of egg donation as it is a routine for us. But we know it is not that simple for you. Though it carries a very high success rate, but psychological implications on the recipient are very high.

The major indications for IVF with donor oocytes in REVIVA are –

  • Premature ovarian failure
  • Menopause
  • Decreased ovarian reserve
  • Endometriosis
  • Recurrent self cycle failures with no proven endometrial or male factor.
  • Genetic causes.

It takes time for the couple to accept the option of Donor eggs, but usually the desire of having a family overcomes this hesitation.

The most important concern of the couple is the quality of genes transmitted to the child. Though the anonymous egg donor is being matched to the recipient as far as possible, the concern always remains in majority of recipient; they are satisfied with their gestational contribution which creates a strong bond.

Another way of dealing with it is to keep the information of type of cycle between the couple only, it will serve you from interrogation eyes and any future problems will be avoided.

On positive note egg donation is associated with many benefit. The most important since eggs are derived from a young woman, they are more likely to produce chromosomally normal embryos and so risk of abortions and birth defects is less.

So, though egg donation is not the first choice of anyone, but it is treatment with very high success rate where it is indicated.

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Why a trend from fresh to frozen embryo transfer?

Why a trend from fresh to frozen embryo transfer?

Whenever a sudden shift is made from fresh embryo transfer to frozen embryo transfer the couple usually have many queries in mind. So, let’s evaluate both and see pros and cons.

Fresh embryos transfer is undergoing ovarian hyper stimulation making of embryos and transferring resultant embryos to uterine cavity in same cycle. In frozen embryo transfer first two steps of controlled ovarian hyper stimulation and process of IVF/ICSI are same but the resultant embryos are frozen using vitrification techniques and not transferred in same cycle. They are thawed and then kept uterine cavity after preparing the uterine cavity.

In patients who are normal or hyper responders the frozen embryo transfers are known to have better results than the fresh embryo transfer . The reason can be that due to ovarian hyper stimulation and high levels of estrogen may have negative impacts on the endometrial receptivity. In some cycles another hormone called progesterone may also be raised, which again decreases embryo implantation rate. Whereas in frozen embryo transfer the body and uterus have already recovered from the impact of hormonal disturbance and hence more receptive.

Because of their reason in patient with PCOS the frozen embryo transfer is associated with higher live birth rate. It also reduces complications like ovarian hypertimulation in these patients.

Another reason where we make a sudden shift from fresh to frozen embryo transfer are when the ovarian stimulation part is good but the endometrial thickness fails to reach an optimal level.

So because of the above reasons we are moving towards more frozen transfer than fresh transfers in self cycle.

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Can Adenomyosis affect my fertility

Can Adenomyosis affect my fertility

Adenomyosis is a condition in which the cells of endometrium (the uterine lining) are present inside the muscular wall of uterus. There is also associated hypertrophy uterine muscles.

Adenomyosis can affect fertility in two ways. Firstly it effects the uterine contractions which helps sperms to reach the tubes. Secondly it also increases the number of toxic cells in the uterine lining which may effect the implantation of embryos.

Adenomyosis may also be associated with endometriosis, a condition in which the uterine lining cells are present in the ovaries or other sites in pelvic. This may further effect the oocyte quality and number, further contributing to difficulty in conception.

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Fertility Preservation for Women Diagnosed with Cancer

Fertility Preservation for Women Diagnosed with Cancer

The most common question asked in IVF counsellings is “Doctor, as we have heard, we need to do complete bed rest after embryo transfer or I can move around. Do you think 15 days leave is sufficient.”

So it’s time to give away this myth forever now. The implantation of embryos placed inside your uterus after embryo transfer depends upon three most important factors   –

  • Quality of eggs
  • Quality of sperms
  • Receptivity of endometrium.

Moreover uterus is a collapsed cavity with opposins walls and a closed cervix. If the embryos are placed inside the uterus at their proper position then few minutes after embryo transfer they remain at their same stable position and in no ways they will fall down even if you stand after the embryo transfer.

Going by literature, various studies have been conducted in which pregnancy rates were compared between the groups who were made to get up 20 minutes after the embryo transfer and those made to rest for varying periods from 3 minutes to even 24 hours in some centers. But no difference was found in the pregnancy rate and the live birth rate. In certain systemic reviews and meta analysis it has been shown that complete bed rest might negatively affect the outcome of IVF/ICSI cycle and the cause may be stress and anxiety mechanism.

So a lot of evidence is against the bed rest factor. Even at Reviva we have seen pregnancy rate comparable between the bed rest and no bed rest groups. I can recall many positive results even in those patients who jump out of bed even half an hour after transfer and those joining their offices the very next day. But inspite of clinical evidence we daily come across patients who had undergone failed cycles at other centers or one of their relatives had undergone treatment elsewhere and were advised complete bed rest after transfer and to the extent that they were kept hospitalized for 24 hours. All this increases the anxiety factor in the patient. Very obvious that lying on bed the whole day is not easy and the thought process is totally focused on one thing and more of stress and negative feelings. How do you think it’s going to help the success rate. And if unluckily the results negative than the female takes the whole burden on her. She thinks it didn’t work because she didn’t have sufficient rest.

So our advice to all our patients, don’t go on house arrest of 2 weeks. Take it easy and carry out with your normal activities. Rest is not going to influence your outcome. So relax, be normal and wait for nature to do its best.

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This is a clinical entity where the uterine lining cells are present outside the uterus, usually, ovaries. The incidence is in reproductive age group.

This condition effects your chances of conceiving by decreasing number and quality of eggs, causing pelvic adhesions and hence tubal blockage toxic microenvironment and also effects endometrium receptivity. (2-10 % in women in general population and 20-30% in infertile group)

Women with endometriosis are 5% less likely to continue naturally even in cases of mild endometriosis. In severe endometriosis the fertility decrease is much higher.

Now since endometriosis is an on-going process, so when diagnosed we tell the patient to plan early. Even after surgical removal of endometriotic cyst, the non visible endometriotic spots continue to release toxins which can effect your fertility. And if patient doesn’t take any treatment after surgery and doesn’t conceive within six months, the pre-surgical state may come again. So postsurgery aggressive treatment is required in cases of grade 3-4 and those with grade 1 and 2 are advised to plan early either naturally or IUI.

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